Preventing Sarcopenia and Promoting Musculoskeletal Health in Middle-Aged Adults: The Role of Exercise and Nutrition

Sarcopenia, once considered an inevitable consequence of ageing, is now recognised as a complex syndrome influenced by lifestyle, disease, and acute physiological stress. As global life expectancy rises, its prevalence is increasing, straining healthcare systems [1, 2] due to its association with disability, frailty, and comorbidities [3]. Prevalence estimates range from 0.2% to 86.5% depending on diagnostic criteria [4]. While typically studied in older adults, evidence suggests earlier onset, with rates between 8%-36% in those under 60 and 10%-27% in those aged 60 and older [4]. This variability partly reflects classification differences, with the European Working Group on Sarcopenia in Older People (EWGSOP2) [5] defining primary sarcopenia (ageing-related) and secondary sarcopenia (driven by disease, inactivity, or malnutrition), each posing distinct diagnostic challenges.