The pons region of the Alzheimer’s disease (AD) brain is one of the last to show amyloid-ß (Aß) deposits and has been suggested to contain neuroprotective compounds. Kisspeptin (KP) is a hormone that activates the Hypothalamic-pituitary- gonadal axis and has been suggested to be neuroprotective against Aß toxicity. The localization of KP, plus the established endogenous neuroprotective compounds corticotropin releasing hormone (CRH) and catalase, in tissue sections from the pons region of a male AD subject have been determined in relation to Aß deposits. Results showed Aß deposits also stained with KP, CRH and catalase antibodies. At high magnification the staining of deposits was either KP or catalase positive and there was only a limited area of the deposits with KP-catalase co-localization. The CRH does not bind Aß, whilst both KP and catalase can bind Aß, suggesting that co- localization in Aß deposits is not restricted to compounds that directly bind Aß. The neuroprotective actions of KP, CRH and catalase were confirmed in vitro and fibrillar Aß preparations were shown to stimulate the release of KP in vitro. In conclusion, neuroprotective KP, CRH and catalase all co-localize with Aß plaque-like deposits in the pons region from a male AD subject.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)