Items where Author is "Doyle, S"

Downes, SG and Owens, RA and Walshe, K and Fitzpatrick, DA and Dorey, A and Jones, GW and Doyle, S (2023) Gliotoxin-mediated bacterial growth inhibition is caused by specific metal ion depletion. Scientific Reports, 13. pp. 1-20. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-023-43300-w

Downes, SG and Doyle, S and Jones, GW and Owens, RA (2023) Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance. Essays in Biochemistry. pp. 1-12. ISSN 1744-1358 DOI: https://doi.org/10.1042/EBC20220222

Doyle, S and Cuskelly, DD and Conlon, N and Fitzpatrick, DA and Gilmartin, CB and Dix, SH and Jones, GW (2022) A Single Aspergillus fumigatus Gene Enables Ergothioneine Biosynthesis and Secretion by Saccharomyces cerevisiae. International Journal of Molecular Sciences, 23 (18). pp. 1-22. ISSN 1422-0067 DOI: https://doi.org/10.3390/ijms231810832

Traynor, AM and Owens, RA and Coughlin, CM and Holton, MC and Jones, GW and Calera, JA and Doyle, S (2021) At the metal-metabolite interface in Aspergillus fumigatus: towards untangling the intersecting roles of zinc and gliotoxin. Microbiology (Reading), 167 (11). pp. 1-15. ISSN 1465-2080 DOI: https://doi.org/10.1099/mic.0.001106

Xu, L and Zhang, H and Cuskelly, DD and Doyle, S and Perrett, S and Jones, GW (2021) Mutational analysis of the Hsp70 substrate-binding domain: Correlating molecular-level changes with in vivo function. Molecular Microbiology. ISSN 1365-2958 DOI: https://doi.org/10.1111/mmi.14671

Traynor, AM and Sheridan, KJ and Jones, GW and Calera, JA and Doyle, S (2019) Involvement of Sulfur in the Biosynthesis of Essential Metabolites in Pathogenic Fungi of Animals, Particularly Aspergillus spp. : Molecular and Therapeutic Implications. Front Microbiol, 10. p. 2859. ISSN 1664-302X DOI: https://doi.org/10.3389/fmicb.2019.02859

Xu, L and Nitika and Hasin, N and Cuskelly, DD and Wolfgeher, D and Doyle, S and Moynagh, P and Perrett, S and Jones, GW and Truman, AW (2019) Rapid deacetylation of yeast Hsp70 mediates the cellular response to heat stress. Scientific Reports, 9 (1). p. 16260. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-019-52545-3

Saleh, AA and Jones, GW and Tinley, FC and Delaney, SF and Alabbadi, SH and Fenlon, K and Doyle, S and Owens, RA (2018) Systems impact of zinc chelation by the epipolythiodioxopiperazine dithiol gliotoxin in Aspergillus fumigatus: a new direction in natural product functionality. Metallomics, 10 (6). pp. 854-866. ISSN 1756-591X DOI: https://doi.org/10.1039/c8mt00052b

Doyle, S and Jones, G and Dolan, SK (2017) Dysregulated gliotoxin biosynthesis attenuates the production of unrelated biosynthetic gene cluster-encoded metabolites in Aspergillus fumigatus. Fungal Biology, 122 (4). pp. 214-221. ISSN 0953-7562 DOI: https://doi.org/10.1016/j.funbio.2017.12.007

Dolan, SK and Bock, T and Hering, V and Owens, RA and Jones, GW and Blankenfeldt, W and Doyle, S (2017) Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus. Open Biol, 7 (2). ISSN 2046-2441 DOI: https://doi.org/10.1098/rsob.160292

Sheridan, KJ and Lechner, BE and Keeffe, GO and Keller, MA and Werner, ER and Lindner, H and Jones, GW and Haas, H and Doyle, S (2016) Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Sci Rep, 6. p. 35306. ISSN 2045-2322 DOI: https://doi.org/10.1038/srep35306

Smith, EB and Dolan, SK and Fitzpatrick, DA and Doyle, S and Jones, GW (2016) Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity. Microbial Cell, 3 (3). 120 - 125. ISSN 2311-2638 DOI: https://doi.org/10.15698/mic2016.03.487

Winkelströter, LK and Dolan, SK and Fernanda Dos Reis, T and Bom, VL and Alves de Castro, P and Hagiwara, D and Alowni, R and Jones, GW and Doyle, S and Brown, NA and Goldman, GH (2015) Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus. G3 (Bethesda, Md.), 5 (7). 1525 - 1539. DOI: https://doi.org/10.1534/g3.115.016766

O'Keeffe, G and Hammel, S and Owens, RA and Keane, TM and Fitzpatrick, DA and Jones, GW and Doyle, S (2014) RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus. BMC genomics, 15. 15- 894. DOI: https://doi.org/10.1186/1471-2164-15-894

Owens, RA and Hammel, S and Sheridan, KJ and Jones, GW and Doyle, S (2014) A proteomic approach to investigating gene cluster expression and secondary metabolite functionality in Aspergillus fumigatus. PloS one, 9 (9). e106942 - ?. DOI: https://doi.org/10.1371/journal.pone.0106942

O'Hanlon, KA and Margison, GP and Hatch, A and Fitzpatrick, DA and Owens, RA and Doyle, S and Jones, GW (2012) Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus. Nucleic acids research, 40 (16). 7806 - 7820. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gks522

Schrettl, M and Carberry, S and Kavanagh, K and Haas, H and Jones, GW and O'Brien, J and Nolan, A and Stephens, J and Fenelon, O and Doyle, S (2010) Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin. PLoS pathogens, 6 (6). e1000952 - ?. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1000952