Items where Author is "Jones, GW"

Downes, SG and Owens, RA and Walshe, K and Fitzpatrick, DA and Dorey, A and Jones, GW and Doyle, S (2023) Gliotoxin-mediated bacterial growth inhibition is caused by specific metal ion depletion. Scientific Reports, 13. pp. 1-20. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-023-43300-w

Downes, SG and Doyle, S and Jones, GW and Owens, RA (2023) Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance. Essays in Biochemistry. pp. 1-12. ISSN 1744-1358 DOI: https://doi.org/10.1042/EBC20220222

Doyle, S and Cuskelly, DD and Conlon, N and Fitzpatrick, DA and Gilmartin, CB and Dix, SH and Jones, GW (2022) A Single Aspergillus fumigatus Gene Enables Ergothioneine Biosynthesis and Secretion by Saccharomyces cerevisiae. International Journal of Molecular Sciences, 23 (18). pp. 1-22. ISSN 1422-0067 DOI: https://doi.org/10.3390/ijms231810832

Traynor, AM and Owens, RA and Coughlin, CM and Holton, MC and Jones, GW and Calera, JA and Doyle, S (2021) At the metal-metabolite interface in Aspergillus fumigatus: towards untangling the intersecting roles of zinc and gliotoxin. Microbiology (Reading), 167 (11). pp. 1-15. ISSN 1465-2080 DOI: https://doi.org/10.1099/mic.0.001106

Yan, P and Zou, Z and Zhang, S and Wang, R and Niu, T and Zhang, X and Liu, D and Zhou, X and Chang, AK and Milton, NGN and Jones, GW and He, J (2021) Defining the mechanism of PDI interaction with disulfide-free amyloidogenic proteins: Implications for exogenous protein expression and neurodegenerative disease. International Journal of Biological Macromolecules, 174. pp. 175-184. ISSN 0141-8130 DOI: https://doi.org/10.1016/j.ijbiomac.2021.01.172

Xu, L and Zhang, H and Cuskelly, DD and Doyle, S and Perrett, S and Jones, GW (2021) Mutational analysis of the Hsp70 substrate-binding domain: Correlating molecular-level changes with in vivo function. Molecular Microbiology. ISSN 1365-2958 DOI: https://doi.org/10.1111/mmi.14671

Traynor, AM and Sheridan, KJ and Jones, GW and Calera, JA and Doyle, S (2019) Involvement of Sulfur in the Biosynthesis of Essential Metabolites in Pathogenic Fungi of Animals, Particularly Aspergillus spp. : Molecular and Therapeutic Implications. Front Microbiol, 10. p. 2859. ISSN 1664-302X DOI: https://doi.org/10.3389/fmicb.2019.02859

Xu, L and Nitika and Hasin, N and Cuskelly, DD and Wolfgeher, D and Doyle, S and Moynagh, P and Perrett, S and Jones, GW and Truman, AW (2019) Rapid deacetylation of yeast Hsp70 mediates the cellular response to heat stress. Scientific Reports, 9 (1). p. 16260. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-019-52545-3

Zhou, X and Lu, X and Qin, S and Xu, L and Chong, X and Liu, J and Yan, P and Sun, R and Hurley, IP and Jones, GW and Wang, Q and He, J (2019) Is the absence of alpha-helix 2 in the appendant structure region the major contributor to structural instability of human cystatin C? Journal of Biomolecular Structure and Dynamics, 37 (17). pp. 4522-4527. ISSN 0739-1102 DOI: https://doi.org/10.1080/07391102.2018.1552625

Gong, W and Hu, W and Xu, L and Wu, H and Wu, S and Zhang, H and Wang, J and Jones, GW and Perrett, S (2018) The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast. Journal of Biological Chemistry. ISSN 1083-351X DOI: https://doi.org/10.1074/jbc.RA118.002691

Saleh, AA and Jones, GW and Tinley, FC and Delaney, SF and Alabbadi, SH and Fenlon, K and Doyle, S and Owens, RA (2018) Systems impact of zinc chelation by the epipolythiodioxopiperazine dithiol gliotoxin in Aspergillus fumigatus: a new direction in natural product functionality. Metallomics, 10 (6). pp. 854-866. ISSN 1756-591X DOI: https://doi.org/10.1039/c8mt00052b

Xu, L and Gong, W and Cusack, SA and Wu, H and Loovers, HM and Zhang, H and Perrett, S and Jones, GW (2017) The β6/β7 region of the Hsp70 substrate-binding domain mediates heat-shock response and prion propagation. Cell Mol Life Sci. ISSN 1420-9071 DOI: https://doi.org/10.1007/s00018-017-2698-3

Dolan, SK and Bock, T and Hering, V and Owens, RA and Jones, GW and Blankenfeldt, W and Doyle, S (2017) Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus. Open Biol, 7 (2). ISSN 2046-2441 DOI: https://doi.org/10.1098/rsob.160292

Sheridan, KJ and Lechner, BE and Keeffe, GO and Keller, MA and Werner, ER and Lindner, H and Jones, GW and Haas, H and Doyle, S (2016) Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Sci Rep, 6. p. 35306. ISSN 2045-2322 DOI: https://doi.org/10.1038/srep35306

Blondel, M and Soubigou, F and Evrard, J and Nguyen, PH and Hasin, N and Chédin, S and Gillet, R and Contesse, MA and Friocourt, G and Stahl, G and Jones, GW and Voisset, C (2016) Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation. Scientific Reports, 6. p. 32117. ISSN 2045-2322 DOI: https://doi.org/10.1038/srep32117

Smith, EB and Dolan, SK and Fitzpatrick, DA and Doyle, S and Jones, GW (2016) Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity. Microbial Cell, 3 (3). 120 - 125. ISSN 2311-2638 DOI: https://doi.org/10.15698/mic2016.03.487

Winkelströter, LK and Dolan, SK and Fernanda Dos Reis, T and Bom, VL and Alves de Castro, P and Hagiwara, D and Alowni, R and Jones, GW and Doyle, S and Brown, NA and Goldman, GH (2015) Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus. G3 (Bethesda, Md.), 5 (7). 1525 - 1539. DOI: https://doi.org/10.1534/g3.115.016766

O'Keeffe, G and Hammel, S and Owens, RA and Keane, TM and Fitzpatrick, DA and Jones, GW and Doyle, S (2014) RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus. BMC genomics, 15. 15- 894. DOI: https://doi.org/10.1186/1471-2164-15-894

Hasin, N and Cusack, SA and Ali, SS and Fitzpatrick, DA and Jones, GW (2014) Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity. BMC genomics, 15. 194 - ?. DOI: https://doi.org/10.1186/1471-2164-15-194

Owens, RA and Hammel, S and Sheridan, KJ and Jones, GW and Doyle, S (2014) A proteomic approach to investigating gene cluster expression and secondary metabolite functionality in Aspergillus fumigatus. PloS one, 9 (9). e106942 - ?. DOI: https://doi.org/10.1371/journal.pone.0106942

Moran, C and Kinsella, GK and Zhang, ZR and Perrett, S and Jones, GW (2013) Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo. G3 (Bethesda, Md.), 3 (8). 1409 - 1418. DOI: https://doi.org/10.1534/g3.113.007112

Xu, LQ and Wu, S and Buell, AK and Cohen, SI and Chen, LJ and Hu, WH and Cusack, SA and Itzhaki, LS and Zhang, H and Knowles, TP and Dobson, CM and Welland, ME and Jones, GW and Perrett, S (2013) Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368 (1617). 20110410 - ?. ISSN 0962-8436 DOI: https://doi.org/10.1098/rstb.2011.0410

Xu, L and Hasin, N and Shen, M and He, J and Xue, Y and Zhou, X and Perrett, S and Song, Y and Jones, GW (2013) Using steered molecular dynamics to predict and assess Hsp70 substrate-binding domain mutants that alter prion propagation. PLoS computational biology, 9 (1). e1002896. ISSN 1553-734X DOI: https://doi.org/10.1371/journal.pcbi.1002896

Fares, MA and Keane, OM and Toft, C and Carretero-Paulet, L and Jones, GW (2013) The roles of whole-genome and small-scale duplications in the functional specialization of Saccharomyces cerevisiae genes. PLoS genetics, 9 (1). e1003176 - ?. ISSN 1553-7390 DOI: https://doi.org/10.1371/journal.pgen.1003176

O'Hanlon, KA and Margison, GP and Hatch, A and Fitzpatrick, DA and Owens, RA and Doyle, S and Jones, GW (2012) Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus. Nucleic acids research, 40 (16). 7806 - 7820. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gks522

Fitzpatrick, DA and O'Brien, J and Moran, C and Hasin, N and Kenny, E and Cormican, P and Gates, A and Morris, DW and Jones, GW (2011) Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes. PloS one, 6 (12). e28684 - ?. DOI: https://doi.org/10.1371/journal.pone.0028684

Schrettl, M and Carberry, S and Kavanagh, K and Haas, H and Jones, GW and O'Brien, J and Nolan, A and Stephens, J and Fenelon, O and Doyle, S (2010) Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin. PLoS pathogens, 6 (6). e1000952 - ?. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1000952