Abstract
Blood platelets are anucleate cells that play a vital role in haemostasis, innate immunity, angiogenesis, and wound healing. However, the inappropriate activation of platelets also contributes to vascular inflammation, atherogenesis, and thrombosis. Platelet activation is a highly complex receptor-mediated process that involves a multitude of signalling intermediates in which Reactive Oxygen Species (ROS) are proposed to play an important role. However, like for many cells, changes in the balance of ROS generation and/or scavenging in disease states may lead to the adoption of maladaptive platelet phenotypes. Here, we review the diverse roles of ROS in platelet function and how ROS are linked to specific platelet activation pathways. We also examine how changes in disease, particularly the plasma oxidised low-density lipoprotein (oxLDL), affect platelet ROS generation and platelet function.
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Divisions: | School of Health |
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Identification Number: | https://doi.org/10.3390/cells14070500 |
Status: | Published |
Refereed: | Yes |
Publisher: | MDPI AG |
Additional Information: | © 2025 by the authors |
Uncontrolled Keywords: | 31 Biological sciences; 32 Biomedical and clinical sciences |
SWORD Depositor: | Symplectic |
Depositing User (symplectic) | Deposited by Hindle, Matthew |
Date Deposited: | 02 Apr 2025 10:40 |
Last Modified: | 03 Apr 2025 23:17 |
Item Type: | Article |
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LT Cheah
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