Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.

Gunnell, D and Oliver, SE and Peters, TJ and Donovan, JL and Persad, R and Maynard, M and Gillatt, D and Pearce, A and Hamdy, FC and Neal, DE and Holly, JM (2003) Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men. British journal of cancer, 88 (11). 1682 - 1686. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6600946

Abstract

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

Identification Number:	https://doi.org/10.1038/sj.bjc.6600946
Status:	Published
Refereed:	Yes
Publisher:	Nature Publishing Group
Uncontrolled Keywords:	Humans; Prostatic Neoplasms; Insulin-Like Growth Factor I; Insulin-Like Growth Factor Binding Protein 3; Diet; Risk Factors; Case-Control Studies; Cross-Sectional Studies; Food Habits; Adult; Aged; Middle Aged; Male
Date Deposited:	09 Jun 2016 14:15
Last Modified:	13 Jul 2024 13:36
Item Type:	Article

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Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.

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